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Avon Fire & Rescue Service (AF&RS) were called to reports of an incident at the Bristol Royal Infirmary at 13:43.
Crews responded to reports of a smell of burning at 13:43.
On arrival, crews found a fire on the second floor of the building, with a secondary fire also discovered, thought to have been caused by an electrical fault.
Using fire extinguishers and two hose reel jets, firefighters were able to extinguish the fire.
Four firefighters wore breathing apparatus for safety.
Following a co-ordinated response from the hospital and emergency services colleagues, the major incident has now been stood down. All roads have now been reopened.
The cause of the incident was accidental ignition, thought to be to due to an electrical fault.
For the latest information on the incident, visit the hospital website.
The public are asked not to visit the hospital and to consider alternative services.
If you have a life threatening emergency please dial 999 for any other urgent medical advice please use NHS 111.
We were called to reports of an incident at the Bristol Royal Infirmary at 13:43.
Crews from Temple, Bedminster, Southmead, Kingswood, Hicks Gate, Patchway and Avonmouth responded and are currently on the scene.
Crews are working with the hospital and emergency services colleagues to resolve the incident. Be assured that all patients, visitors and colleagues are safe.
The only road closed is Upper Maudlin Street inbound (for motorists travelling towards The Bear Pit Roundabout).
We would ask you avoid the area where possible, and follow NHS advice on accessing care.